In your apache config file (httpd.conf) add the following :
LoadModule rewrite_module modules/mod_rewrite.so <Directory "path_to_your_drupal_dir"> AllowOverride All RewriteEngine on RewriteBase / RewriteCond %{REQUEST_FILENAME} !-f RewriteCond %{REQUEST_FILENAME} !-d RewriteRule ^(.*)$ index.php?q=$1 [L,QSA] </Directory>
Test your configuration by accessing your_host/user/login (instead of ?q=user/login).